Protein Details: Cation channel sperm-associated protein 1

Protein ID

ICDB_Pro_1362

Protein Name

Cation channel sperm-associated protein 1

Gene Name

Catsper1

Organism

Mus musculus (Mouse)

Length

686 amino acids

AlphaFoldDB

AF-Q91ZR5-F1-model_v4.pdb

Function

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility; a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.

Sequence

MDQSSRRDESYHETHPGSLDPSHQSHPHPHPHPTLHRPNQGGVYYDSPQHGMFQQPYQQHGGFHQQNELQHLREFSDSHDNAFSHHSYQQDRAGVSTLPNNISHAYGGSHPLAESQHSGGPQSGPRIDPNHHPHQDDPHRPSEPLSHPSSTGSHQGTTHQQYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSHHGEHPHHKEQRHYHGDHMHHHIHHRSPSASQLSHKSHSTLATSPSHVGSKSTASGARYTFGARSQIFGKAQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFLSIYVLEAVLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEALKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDDDYGK

PDB Structures

7EEB

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Testis-specific

DOI ID

10.1038/35098027; 10.1093/molbev/msi178; 10.1073/pnas.2536658100; 10.1093/humrep/deh043; 10.1074/jbc.m501430200; 10.1038/nature04417; 10.1016/j.ydbio.2006.11.007; 10.1074/jbc.m701083200; 10.1093/molehr/gam009; 10.1073/pnas.0610286104; 10.1095/biolreprod.109.077107; 10.1038/nature09767; 10.1038/ncomms1153; 10.1016/j.celrep.2021.110226; 10.1038/s41586-021-03742-6

RefSeq

NP_647462.1